NIGELLA SATIVA and YOUR IMMUNITY
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Nowadays most of us confront one of the most commonly used words- "immunity" which is our body's defense mechanism to fight against diseases.
Immunity is the functional outcome of the immune system. Therefore, it is very important to boost your immune system to keep yourself disease free.
Healthy lifestyle and a balanced diet are key to maintain your health.
But unwanted exposure to environmental toxins, infection-causing agents or other disease-causing agents provoke different ailments, which can be naturally protected by strong immunity.
Immunity is the functional outcome of the immune system. Therefore, it is very important to boost your immune system to keep yourself disease free.
Healthy lifestyle and a balanced diet are key to maintain your health.
But unwanted exposure to environmental toxins, infection-causing agents or other disease-causing agents provoke different ailments, which can be naturally protected by strong immunity.
Although immunity is a natural defense mechanism of the body, dysregulation of the immune system leads to autoimmunity.
In clinical practice, immunity boosters have a specific therapeutic role to promotes normal functioning of the immune system.
In clinical practice, immunity boosters have a specific therapeutic role to promotes normal functioning of the immune system.
Nigella sativa is one of the most promising herbal remedies for poor immunity. However, the action of Nigella sativa not only
activate the immune system against different disease-causing agent but it also assists to maintain the homeostasis of the immune system functioning to prevent autoimmune disease conditions.
READ: NIGELLA SATIVA TREATS COLDS AND FLU
IMMUNOMODULATORS - WHAT IS AND THE KEY TO HEALTH
activate the immune system against different disease-causing agent but it also assists to maintain the homeostasis of the immune system functioning to prevent autoimmune disease conditions.
READ: NIGELLA SATIVA TREATS COLDS AND FLU
IMMUNOMODULATORS - WHAT IS AND THE KEY TO HEALTH
How Nigella sativa provides immunomodulatory effects?
The Nigella sativa extract or oil extracted from the seeds of Nigella sativa has an antagonistic effect on muscarinic receptors and provides the relaxing effect, whereas it stimulates β-adrenoceptors. In addition, this herbal therapeutic agent can inhibit histamine receptors activity. It blocks calcium channels and releases potassium channels. [1]
The Nigella sativa extract or oil extracted from the seeds of Nigella sativa has an antagonistic effect on muscarinic receptors and provides the relaxing effect, whereas it stimulates β-adrenoceptors. In addition, this herbal therapeutic agent can inhibit histamine receptors activity. It blocks calcium channels and releases potassium channels. [1]
What are the health benefits obtained from Nigella sativa due to its immunomodulatory effects?
Following are the health benefits obtained from Nigella sativa:
Nigella sativa as an immunomodulator can anti-tumor and cancer protective agent
In a traditional medicine, Nigella sativa is used as an immunity booster. But this herbal therapeutic agent plays a unique role as an immune system modulator. Nigelia sativa as an immune modulator can able to prevent diseases by maintaining the homeostasis of the immunity functioning. Natural killer (Nk) cells present in the immune system acts as an anti-tumor activity.
Research evidence showed that Nigella sativa stimulates the activity of Nk cells and provides anti-tumor activity. Researchers also expected that Nigella sativa can prevent cancer due to enhancing the activity of Nk cells. [2
Following are the health benefits obtained from Nigella sativa:
Nigella sativa as an immunomodulator can anti-tumor and cancer protective agent
In a traditional medicine, Nigella sativa is used as an immunity booster. But this herbal therapeutic agent plays a unique role as an immune system modulator. Nigelia sativa as an immune modulator can able to prevent diseases by maintaining the homeostasis of the immunity functioning. Natural killer (Nk) cells present in the immune system acts as an anti-tumor activity.
Research evidence showed that Nigella sativa stimulates the activity of Nk cells and provides anti-tumor activity. Researchers also expected that Nigella sativa can prevent cancer due to enhancing the activity of Nk cells. [2
Nigella sativa as an immunomodulator can prevent infections
Bone marrow and spleen are two important organs associated with your immune system. B lymphocytes are a type of white blood cells (WBCs) are produced in bone marrow. Spleen is one of the major organs of the lymphatic system and assists to produce T lymphocytes in the in the thymus.
Both mature T cells and B cells can suppress the pathogenic organisms including bacteria, fungi, and viruses. An animal research conducted on mice showed that Nigella sativa treated animals had white blood cells count more than the control group.
This study report indicates that Nigella sativa ingestion can increase Nigella sativa ingestion can increase WBC count by promoting bone marrow functionality and also support spleen health. This positive activity of Nigella sativa improve overall immunity. A study research showed that showed that Nigella sativa has a prophylactic effect against Candida albicans infection. [2]
Hepatitis C is viral condition leads to liver inflammation. According to the WHO 2015 data, the prevalence of hepatitis C is increasing and globally 23.7 population per 100000 population suffered from hepatitis C. [3] A clinical research showed that Nigella sativa can reduce viral load and improve the condition. In addition, Nigella sativa can decrease oxidative stress, and assist to alleviate infection early. [4]
Bone marrow and spleen are two important organs associated with your immune system. B lymphocytes are a type of white blood cells (WBCs) are produced in bone marrow. Spleen is one of the major organs of the lymphatic system and assists to produce T lymphocytes in the in the thymus.
Both mature T cells and B cells can suppress the pathogenic organisms including bacteria, fungi, and viruses. An animal research conducted on mice showed that Nigella sativa treated animals had white blood cells count more than the control group.
This study report indicates that Nigella sativa ingestion can increase Nigella sativa ingestion can increase WBC count by promoting bone marrow functionality and also support spleen health. This positive activity of Nigella sativa improve overall immunity. A study research showed that showed that Nigella sativa has a prophylactic effect against Candida albicans infection. [2]
Hepatitis C is viral condition leads to liver inflammation. According to the WHO 2015 data, the prevalence of hepatitis C is increasing and globally 23.7 population per 100000 population suffered from hepatitis C. [3] A clinical research showed that Nigella sativa can reduce viral load and improve the condition. In addition, Nigella sativa can decrease oxidative stress, and assist to alleviate infection early. [4]
Nigella sativa as an immunomodulator can prevent Autoimmune diseases
Dysregulation of immune system functioning often leads to autoimmunity. The autoimmune disease occurs due to the immune system mediated destructive self-antigen production. This leads to tissue damage and functional failure of the organs. Both, inflammatory and non-inflammatory conditions are associated with autoimmune diseases. Hashimoto’s disease, rheumatoid arthritis, allergic conditions are few common examples of the autoimmune diseases.
Dysregulation of immune system functioning often leads to autoimmunity. The autoimmune disease occurs due to the immune system mediated destructive self-antigen production. This leads to tissue damage and functional failure of the organs. Both, inflammatory and non-inflammatory conditions are associated with autoimmune diseases. Hashimoto’s disease, rheumatoid arthritis, allergic conditions are few common examples of the autoimmune diseases.
- Nigella sativa can improve Hashimoto’s disease, as a human research study showed that patients treated with 2 g of Nigella sativa or even lesser doses can improve serum thyroid hormone (T3) within eight weeks treatment period by improving thyroid functioning. In addition, Hashimoto’s disease affected patients are also get benefitted with Nigella sativa treatment by maintaining body weight. [5]
- An autoimmune encephalomyelitis condition can also be improved by Nigella sativa treatment. A pre-clinical study reported Nigella sativa as an immunomodulator can prevent the relapsing of autoimmune encephalomyelitis in the experimental animal. [2]
- In allergic condition, mast cells are over-activated and histamine and different pro-inflammatory mediators released. allergic rhinitis, bronchial asthma, atopic eczema are some common allergic condition associated with autoimmunity. Nigella sativa decreases IgE, eosinophil count and suppress immunity due to its immuno-modulator effect and prevent exaggeration of the allergic reaction. [6]
- Food allergy often causes allergic diarrhea. Nigella sativa can decrease mast cells activation present in the intestine and blood plasma cellular structures. Thus it treats allergic diarrhea. [2]
Nigella sativa as an immunomodulator can prevent Inflammatory disease conditions (rheumatoid arthritis)
Different immune system mediated inflammatory conditions arise due to increasing of Th2 cytokines, eosinophils, IgE and IgG1 levels. A preclinical research showed that treatment with Nigella sativa can significantly decrease these levels and lessen the inflammatory conditions related discomfort. [1] A human research study showed that Nigella sativa can improve rheumatoid arthritis condition. [7]
Direction for application
Dosing
Nigella sativa seeds are used as a supplement to boost immunity. For this 2gm dosing per day for one month treatment period improve the immunity almost 32 percent to 75 percent, as it improves intracellular foreign body killing power and also increases engulfing (phagocytic) activity of macrophages. [8]
Treating patients with Rheumatoid arthritis
Oral administration of Nigella sativa oil 500 mg twice a day for 30 days can significantly improve morning stiffness, joint pain, and inflammation. [7]
How to get the best result
The combination with other natural immunity boosters synergistically boosts your immunity. For combination therapy, you need following ingredients and need follow the direction.
Ingredients
• Honey - 2 tablespoonful
• Nigella sativa seeds - 2 teaspoons
• Ginger powder - 2 teaspoons
• Nuts (almond or walnut) - 1 tablespoonful (avoid this if you have nut allergy)
Direction
All the ingredient mixed properly in a container and take it twice a day. Prefer to prepare freshly this preparation to get optimum result.
Note: It is preferable that instead of raw Nigella sativa seeds use Nigella sativa oil for easy palatability. [9]
Different immune system mediated inflammatory conditions arise due to increasing of Th2 cytokines, eosinophils, IgE and IgG1 levels. A preclinical research showed that treatment with Nigella sativa can significantly decrease these levels and lessen the inflammatory conditions related discomfort. [1] A human research study showed that Nigella sativa can improve rheumatoid arthritis condition. [7]
Direction for application
Dosing
Nigella sativa seeds are used as a supplement to boost immunity. For this 2gm dosing per day for one month treatment period improve the immunity almost 32 percent to 75 percent, as it improves intracellular foreign body killing power and also increases engulfing (phagocytic) activity of macrophages. [8]
Treating patients with Rheumatoid arthritis
Oral administration of Nigella sativa oil 500 mg twice a day for 30 days can significantly improve morning stiffness, joint pain, and inflammation. [7]
How to get the best result
The combination with other natural immunity boosters synergistically boosts your immunity. For combination therapy, you need following ingredients and need follow the direction.
Ingredients
• Honey - 2 tablespoonful
• Nigella sativa seeds - 2 teaspoons
• Ginger powder - 2 teaspoons
• Nuts (almond or walnut) - 1 tablespoonful (avoid this if you have nut allergy)
Direction
All the ingredient mixed properly in a container and take it twice a day. Prefer to prepare freshly this preparation to get optimum result.
Note: It is preferable that instead of raw Nigella sativa seeds use Nigella sativa oil for easy palatability. [9]
PATRICK DELVES ON INCREASE ANTIBODIES
300 MG OF VITAMIN 6
30 MG OF ZINC
5000MG OF BUFFERED VITAMIN C
2000IU OF VITAMIN B12
ALSO: ENCHINACEA, CHAGA, ELDERBERRY, ASTRAGALUS
YOU MUST TAKE : CHERRIES, GOOSEBERRIES, BLACKBERRIES, RASPBERRIES, LENTILS
300 MG OF VITAMIN 6
30 MG OF ZINC
5000MG OF BUFFERED VITAMIN C
2000IU OF VITAMIN B12
ALSO: ENCHINACEA, CHAGA, ELDERBERRY, ASTRAGALUS
YOU MUST TAKE : CHERRIES, GOOSEBERRIES, BLACKBERRIES, RASPBERRIES, LENTILS
References
- Mohammad-Hossein Boskabady, Rana Keyhanmanesh, Saeed Khameneh, Yousef Doostdar, Mohammad-Reza Khakzad. Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs. J Zhejiang Univ Sci B. 2011 Mar; 12(3): 201–209. doi: 10.1631/jzus.B1000163. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048935/
- Aftab Ahmad, Asif Husain, Mohd Mujeeb, Shah Alam Khan, Abul Kalam Najmi, Nasir Ali Siddique, Zoheir A. Damanhouri, Firoz Anwar. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 2013 May; 3(5): 337–352. doi: 10.1016/S2221-1691(13)60075-1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642442/
- Hepatitis C, Fact sheet. World Health Organization. Updated October 2017. http://www.who.int/mediacentre/factsheets/fs164/en/
- Barakat EM, El Wakeel LM, Hagag RS. Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol. 2013 Apr 28;19(16):2529-36. doi: 10.3748/wjg.v19.i16.2529. https://www.ncbi.nlm.nih.gov/pubmed/23674855
- Mahdieh Abbasalizad Farhangi, Parvin Dehghan, Siroos Tajmiri, Mehran Mesgari Abbasi. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) – 1, Nesfatin-1 and anthropometric features in patients with Hashimoto’s thyroiditis: a randomized controlled trial. BMC Complement Altern Med. 2016; 16: 471.Published online 2016 Nov 16. doi: 10.1186/s12906-016-1432-2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112739/
- Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, Kiesewetter H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res. 2003 Dec;17(10):1209-14. https://www.ncbi.nlm.nih.gov/pubmed/14669258
- Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012 Aug;26(8):1246-8. doi: 10.1002/ptr.3679. Epub 2011 Dec 12. https://www.ncbi.nlm.nih.gov/pubmed/22162258
- Işik H, Cevikbaş A, Gürer US, Kiran B, Uresin Y, Rayaman P, Rayaman E, Gürbüz B, Büyüköztürk S. Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients. Med Princ Pract. 2010;19(3):206-11. doi: 10.1159/000285289. Epub 2010 Mar 29. https://www.ncbi.nlm.nih.gov/pubmed/20357504
- The Blessed Seed. http://theblessedseed.blogspot.in/2012/01/for-energy-and-improved-immune-system.html